Theories about aging


You need to know what happens to your body as you age
in order to understand how to prevent this.

Spend some time and energy on this.
I assure you it is worth it.

 

Click on a theory to jump to the subject

 

Free Radicals & Oxidative Stress

Free radicals are unstable and highly reactive molecules.
They lack an electron and will steal it from you. The reaction is called oxidation.
They attack any molecule the encounter inside us. Picking cells apart. Even DNA.
This leads to disease, aging and eventually; death.

Antioxidants protects our body against these attacks. They sacrifice themselves to these scavengers in order to prevent attacks on our cells.

Free radicals are everywhere. We produce them ourselves and we breath them in from the air around us.

If the amount of free radicals exceeds the amount of antioxidants in our bodies. The body will encounter oxidative stress. The body's cells are under attack.

Vegetables and berries are filled with antioxidants. Cocoa, fruit and mushrooms as well. Endulge!

Vegetables and berries are filled with antioxidants. Cocoa, fruit and mushrooms as well. Endulge!

Oxidation leads to:

  • Inflammation
  • Heart disease
  • Cancer
  • Premature aging
  • Neurologic disease
  • DNA mutation

Antioxidants flourish in plenty.
We make them ourselves! These are called Superoxide Dismutase (SOD), Catalase and Gluthation. Among others, but these are the big three. Unfortunately as we age the production of these big three decreases.

But, you can stimulate your body to produce more.

You can also up your body's antioxidant level by eating antioxidant rich food.
Beans, berries, fruit and vegetables are packed with antioxidants. The same goes for spices, tea, nuts and grains.

Some vitamins and minerals can actually function as antioxidants if needed to.
Vitamin C and E are examples of a few. As are the minerals Selenium and Zink.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249911/
https://www.ncbi.nlm.nih.gov/pubmed/11938555

 
 

Telomeres & Cells

Telomeres are your DNA's protective shoelace-caps. When torn, your DNA can not replicate any more.

Telomeres are your DNA's protective shoelace-caps. When torn, your DNA can not replicate any more.


The thread of life?

At the end of each chromosome in our cells you find telomeres.
They are repeated sequences of non-coding DNA protection the very important coding DNA,.

Imagine the plastic tubes at the end of your shoelaces protecting them from wear and tear.
Well, that's what telomeres do. They are disposable elongations of the chromosome.

Every time a cell divides the chromosome desteriorates becoming shorter.

When the telomeres have run out the cell will stop dividing. It will stop functioning or die.

Our body has enzymes, telomerases, that continuosly build more telomeres.
Yet it cant keep up with the rapid loss.

How can we stimulate telomerase to work harder?

These supplements help:

 

http://www.psyneuen-journal.com/article/S0306-4530(15)30021-4/fulltext
http://cancerres.aacrjournals.org/content/59/23/5917.short

 
 

A.G.E.

dependent-100343_640.jpg

There is a continous "sugarification" of our tissue. The result: AGE.

AGE is short for Advanced Glycemic End-products. They are produced when sugars bind to molecules in our body.

AGE leads to:

  • Premature aging
  • Eye disease
  • Stiff arteries
  • Atherosclerosis
  • Brain disease and stroke
  • Alzheimer's disease
  • Wrinkles and poor skin quality
  • Apoptosis (cell death)
  • Inflammation

You can avoid AGE simply by avoiding carbohydrates.
But you can also add AGE inhibitors to your diet. Substances that bind to sugar or stops the formation of AGE in other ways. Carnosine, Pterostilbene and Curcumin are examples of AGE inhibitors.

Read more about AGE and AGE inhibitors in the blog

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3704564/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342583/
http://www.dermalinstitute.com/us/library/23_article_What_Causes_Skin_Aging_.html

 
 

IGF-1

Insulin Growth Factor - 1, or insulin-like growth factor, is one of many hormones in our body.
This one stimulates growth.

Too much IGF-1 seems to be connected with a higher chance of developing several types of cancer.
Too low levels of IGF-1 increases your chance of heart disease and diabetes.
A blood test to determine your levels can be take by your doctor.

Get your protein from a non animal source. Like nuts, beans and seeds.

Get your protein from a non animal source. Like nuts, beans and seeds.

From the age 20-30 years the amount of IGF-1 declines.
Lifestyle and food consumption can increase or decrease IGF-1 levels.

Low calorie intake and fasting can reduce IGF-1 levels.
A low protein diet may do the same. Or a diet low in the amino acid Methionine.

Animal protein tend to be high i Methionine.

Exercise, high calorie intake and the consumption of animal proteins increase IGF-1 levels.

These are normal values of IGF-1:

  • 182 - 780 ng/mL when 16 - 24 years old

  • 114 - 492 ng/mL when 25 - 39 years old

  • 90 - 360 ng/mL when 40 - 54 years old

  • 71 - 290 ng/mL when 55 or older


https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.2011-1377#sthash.ILNE6e6z.dpuf
http://onlinelibrary.wiley.com/doi/10.1111/j.1474-9726.2005.00152.x/full
https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=167&contentid=insulin_like_growth_factor

 

 
 

UV-radiation

The beloved varmth of the sun comes with a price.
UVA and UVB radiation, both from the sun and human made sources, will damage your skin and eyes.

Avoid skin cancer by taking precausions

Avoid skin cancer by taking precausions

UV-radiation leads to:

  • Eye disease
  • Wrinkles and poor skin quality
  • Skin cancer
  • Age spots/Liver spots
  • Free Radicals
     

How to protect yourself from damage:

  • Avoid the sun between noon and 15:00 during the day
  • Wear sunscreen, SPF 20-30, UVA+UVB, all year around
  • Wear sunglasses with UV protection
  • Use a safe self tanning lotion for color
  • Attach a UV film on your windows. Car and home.

Even at winter of on a cloudy day the radiation will reach us. Increasingly damaging your skin more and more.

 

http://www.nature.com/scitable/blog/green-science/dangers_of_the_sun

 
 

Intracellular og extracellular "junk"


Our body is highly effective when it comes to ridding it self of unwanted materials.
But its not perfect. Junk will build up.

Amyloid plaque and Lipocuscine are two kinds of junk that accumulates with age. These cause age -related problems.

Amyloid plaque and Lipocuscine are two kinds of junk that accumulates with age. These cause age -related problems.

Amyloid plaque in the brain leading to dementia.
Lipofuscine compromising your eye health. Weakening your vision over time.
Oxidized cholesterol in in immune cells leading to atherosclerosis. Which leads to heart attack, anurism and stroke.

These are all natural bi-products of the metabolism.
But difficult, if not impossible, for the body to clean out.


Luckily you might be able to help your body getting rid of this junk. Or at least limit the formation!

Extract of bilberry seem to have some protective properties against the formation of all of the above. It is assumed the active ingredient is Pterostilbene.
Antioxidants and AGE-inhibitors also provide protection from junk formation.

Researchers work one developing a vaccine to reduce the build up of amyloid plaque in the brain.
There is also work being done to see if enzymes and reduce Lipofucine build up.
Using bacteria as a treatment may be in store! ;)

Read what the blog says about junk build up!


http://www.sens.org/research/introduction-to-sens-research/intracellular-junk
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3649683/
https://www.fightaging.org/archives/2008/03/lipofuscin-and-agerelated-macular-degeneration/

 
 

Mutation & Cancer

How to prevent cancer? DNA damage can lead to cancer, help your body prevent DNA damage!

How to prevent cancer? DNA damage can lead to cancer, help your body prevent DNA damage!

What is mutation?

Mutation is when an error in the replication of DNA or mtDNA occur.
They can be with no significance or they can lead to cell death and cancer.
You never know until it happens.

Mutations occur spontaneous through out life.
Yet there are factors contributing to the likelihood of mutation and cancer development.

The more mutations happening the bigger the risk.

Oxidative stress increase the frequency of mutations.
Some chemicals like parabens and phtalates are carcinogenic(directly causing cancer).
Clothes, shoes, skin care, soap, detergent, food, interior, toys, sports articles... You name it! They all might contain poisonous chemicals.

Radiation is also a problem. Both the sun, radioactive sources in the ground and electromagnetic man made sources can potentially do harm.

Your lifestyle will affect the likelihood of mutations and cancer.
You can increase of decrease mutation frequency by life choices.

 

Prevent cancer:

  • Exercise regularly
  • Vegetables, fruits and berries
  • Specially green vegetables like brussel sprouts
  • Fresh food with strong colors
  • Spices like turmeric and ginger
  • Garlic and onion
  • Keep away or keep distance from electromagnetic sources
  • Wear clothes made of natural fibers, not plastic
  • Let kids play with wooden toys, not plastic
  • Choose organic if possible
  • Protect yourself from the sun
  • Avoid toxic chemicals in soap, tooth paste etc
  • Get HPV vaccination
  • Drink a lot of strong green tea
  • Supplements: EGCg, Curcumin, vitamin C...

Increase cancer risk by:

  • Sedative lifestyle
  • Smoking
  • Sugar and food with high GI
  • Red meat
  • Processed meat, specially smoked
  • Burnt, specially potato and meat
  • Inflammation
  • Alcohol
  • Chemicals like BPA, Parabener, Ftalater, Diacetyl
  • Unprotected sex
  • Too much omega 6 in realtion to omega 3

Even with cancer prone genetics you can prevent cancer through lifestyle
(Ambry Genetics)!

 

Sources:
Anne Chomyn og Guiseppe Attardived, 2003. "MtDNA mutations in aging and apoptosis"
https://kreftforeningen.no/om-kreft/hva-er-kreft/
https://ghr.nlm.nih.gov/primer/mutationsanddisorders/genemutation
https://kreftforeningen.no/forebygging/andre-mulige-risikofaktorer/hormonforstyrrende-stoffer-og-kreft/
https://www.ncbi.nlm.nih.gov/pubmed/11884413
https://thetruthaboutcancer.com/sugar-white-death/
https://www.cancer.org/cancer/cancer-causes/infectious-agents.html

 

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